NEWS SPECIAL: Multi-resistant bacteria and how to fight them
Antibiotics have been a highly effective weapon in the fight against bacterial infections for decades, but now this weapon is losing its power. The number of bacteria becoming resistant to this kind of drugs is steadily on the rise. As this will be one of the major health problems of the future, new methods for treatment will developed. Our news special combines three current press releases from the Technical University of Munich (TUM) about “Multi-resistant bacteria and how to fight them”.
Munich student team develops new production method for viruses that attack bacteria
Bacteria that become resistant to known antibiotics are on rise. A team of students from the Technical University of Munich (TUM) and Ludwig-Maximilians University (LMU) have developed a new method to produce bacteriophages, the natural enemies of bacteria, which can be used as alternative treatments for bacterial infections. The team took second place among over 350 teams in the renowned global iGEM competition.
This news on the web: https://www.tum.de/nc/en/about-tum/news/press-releases/detail/article/35083/
New targets in the battle against antibiotic resistance
More and more bacteria are resistant to available antibiotics. A team of chemists from the Technical University of Munich (TUM) now presents a new approach: they have identified important enzymes in the metabolism of staphylococci. Blocking these enzymes in a targeted manner would allow the pathogens to be starved.
This news on the web: https://www.tum.de/nc/en/about-tum/news/press-releases/detail/article/35087/
High levels of enterotoxins of multi-resistant bacteria make them more dangerous
Staphylococcus aureus bacteria can cause numerous diseases, such as skin infections, pneumonia and blood poisoning (sepsis). The strong immune response triggered by the bacteria is an aggravating factor here. One reason for this lies in specific bacterial toxins – as established by a team from the Technical University of Munich (TUM) and University of Tübingen. These toxins reduce the amount of cells capable of suppressing the immune response. So multi-resistant strains, which produce very high levels of enterotoxin, become even more dangerous.
This news on the web: https://www.tum.de/nc/en/about-tum/news/press-releases/detail/article/35080/
Hoegl et al.: Mining the cellular inventory of pyridoxal phosphate-dependent enzymes with functionalized cofactor mimics, Nature Chemistry, Oct. 8, 2018 – DOI: 10.1038/s41557-018-0144-2
Stoll et al.: Staphylococcal Enterotoxins Dose-Dependently Modulate the Generation of Myeloid-Derived Suppressor Cells, Frontiers in Cellular and Infection Microbiology, September 13, 2018, DOI: 10.3389/fcimb.2018.00321 (Open Access)