Study shows that fungus from the intestinal mucosa affects lung health
Our microbiome can impair our immune system through a harmless fungus / Writing in the journal Cell, a research team from Cologne and Kiel describes the mechanism of ‘immune cross-reactivity’
The composition of the microbiome – the countless bacteria, fungi and viruses that colonize our body surface, skin, intestines or lungs – makes a decisive contribution to human health or disease. However, biological mechanisms that cause inflammations in the microbiome are still largely unknown. Together with a group of researchers from the University of Kiel and the University Hospital of Schleswig-Holstein, Professer Dr. Oliver Cornely (CECAD Cluster of Excellence for Aging Research at the University of Cologne and head of the Center of Excellence for Invasive Fungal Diseases at Cologne University Hospital) has deciphered a mechanism by which specific intestinal microbiota amplify inflammatory reactions in the lungs. The results of the study, published in Cell, could accelerate the development of new therapies for common diseases.
‘The fungus Candida albicans, which colonizes the intestines, skin and mucous membranes, is actually harmless’, Cornely said. ‘However, our study has shown that Candida albicans affects the balance of our immune system.’
Candida albicans stimulates the immune system to produce specific defence cells, so-called Th17 cells. However, some of these Th17 cells then attack other fungi, such as Aspergillus fumigatus. This phenomenon is called cross-reactivity. The research showed that immune-compromised individuals have an increased level of cross-reactive Th17 cells in their lung tissue. This concentration is associated with a deterioration of these patients’ health. The protective Th17 reaction in the intestine seems to amplify pathogenic immune processes in the lungs.
‘With this observation, we were able to show for the first time how a single member of the microbiome, Candida albicans, influences the specific immune response to a large group of other microbes. Immune cross-reactivity is probably a common mechanism by which the microbiome manipulates the immune system – with both protective and harmful effects’, Cornely remarked.
Deciphering such specific effects of individual microbes will in future contribute to the development of targeted therapies.
Professor Dr. Oliver Cornely
Principal Investigator CECAD and Clinical Trials Centre Cologne
+49 221 478-85523
Press and Communications Team:
PR and Communications Officer/Faculty of Medicine, University of Cologne
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Human Anti-fungal Th17 Immunity and Pathology Rely on Cross-Reactivity against Candida albicans. URL: https://www.cell.com/cell/fulltext/S0092-8674(19)30104-7